Issue 5, 2019

Pt nanozyme for O2 self-sufficient, tumor-specific oxidative damage and drug resistance reversal

Abstract

Herein, an ultrathin Pt nanozyme has been developed. The Pt nanozyme exhibited both oxidase and peroxidase-mimetic properties, leading to relieved hypoxia and specific oxidative damage in tumor cells in a cascade manner. Meanwhile, hydrophilic Pt2+ was released sustainably under tumor acidity. These properties endow the Pt nanozyme with great potential in killing drug resistant tumor cells while not damaging normal cells.

Graphical abstract: Pt nanozyme for O2 self-sufficient, tumor-specific oxidative damage and drug resistance reversal

Supplementary files

Article information

Article type
Communication
Submitted
15 Feb 2019
Accepted
11 Apr 2019
First published
12 Apr 2019

Nanoscale Horiz., 2019,4, 1124-1131

Pt nanozyme for O2 self-sufficient, tumor-specific oxidative damage and drug resistance reversal

Z. Ma, L. Wu, K. Han and H. Han, Nanoscale Horiz., 2019, 4, 1124 DOI: 10.1039/C9NH00088G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements