Issue 1, 2020
From the journal:

RSC Medicinal Chemistry

Meridianin D analogues possess antibiofilm activity against Mycobacterium smegmatis†

Sara M. Brackett,‡a   Karlie E. Cox,‡a   Samantha L. Barlock,a   William M. Huggins,b   David F. Ackart,c   Randall J. Bassaraba,c   Roberta J. Melandera  and  Christian Melander ORCID logo *a  

* Corresponding authors

a Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA
E-mail: cmelande@nd.edu

b Department of Chemistry, North Carolina State University, Raleigh, NC 27695, USA

c Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA

Abstract

The formation of bacterial biofilms significantly decreases the efficacy of antibiotic treatments. Herein, we've investigated the antibiofilm properties of the natural product meridianin D and a library of analogues against Mycobacterium smegmatis. As a result, we discovered several analogues that both inhibit and disperse M. smegmatis biofilms.

Graphical abstract: Meridianin D analogues possess antibiofilm activity against Mycobacterium smegmatis

  • This article is part of the themed collection: Tuberculosis
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Article information

DOI
https://doi.org/10.1039/C9MD00466A
Article type
Research Article
Submitted
30 Sep 2019
Accepted
29 Oct 2019
First published
16 Dec 2019

RSC Med. Chem., 2020,11, 92-97

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Meridianin D analogues possess antibiofilm activity against Mycobacterium smegmatis

S. M. Brackett, K. E. Cox, S. L. Barlock, W. M. Huggins, D. F. Ackart, R. J. Bassaraba, R. J. Melander and C. Melander, RSC Med. Chem., 2020, 11, 92 DOI: 10.1039/C9MD00466A

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