K. Naresh Babu, Souvik Pal, Arindam Khatua, Avishek Roy and Alakesh Bisai
Org. Biomol. Chem., 2022,20, 127-131
DOI:
10.1039/D1OB02048J,
Communication
The catalytic asymmetric synthesis of 3-allyl-3′-aryl 2-oxindoles has been shown via the Pd(0)-catalyzed decarboxylative allylation of allylenol carbonates. This methodology provides access to a variety of 2-oxindole substrates (5a–v) with all-carbon quaternary stereocenters (up to 94% ee) at the pseudobenzylic position under additive-free and mild conditions. The synthetic potential of this method was shown by the asymmetric synthesis of the tetracyclic core of the diketopiparazine-based alkaloid azonazine (11).