Issue 37, 2023

Electrochemical direct C–H mono and bis-chalcogenation of indolizine frameworks under oxidant-free conditions

Abstract

Herein, we disclosed a sustainable electrochemical approach for site-selective C–H mono and bis-chalcogenation (sulfenylation or selenylation) of indolizine frameworks. Diversely functionalized disulfides and diselenides possessing EDGs and EWGs were successfully reacted with a variety of indolizines to directly access sulfenylated/selenylated indolizines in 40–96% yields. A mechanistic radical pathway was also validated with control experiments and cyclic voltammogram data.

Graphical abstract: Electrochemical direct C–H mono and bis-chalcogenation of indolizine frameworks under oxidant-free conditions

Supplementary files

Article information

Article type
Paper
Submitted
11 Jul 2023
Accepted
01 Sep 2023
First published
04 Sep 2023

Org. Biomol. Chem., 2023,21, 7643-7653

Electrochemical direct C–H mono and bis-chalcogenation of indolizine frameworks under oxidant-free conditions

A. Chouhan, K. Ucheniya, L. Yadav, P. K. Jat, A. Gurjar and S. S. Badsara, Org. Biomol. Chem., 2023, 21, 7643 DOI: 10.1039/D3OB01109G

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