From the journal:

Chemical Communications

mRNA delivery with templated dynamic covalent polymers†

José García Coll, ORCID logo a   Lamiaa M. A. Ali, ORCID logo a   Javier Montenegro, ORCID logo b   Nadir Bettache ORCID logo *a  and  Sébastien Ulrich ORCID logo *a  

* Corresponding authors

a Institut des Biomolécules Max Mousseron (IBMM), Université de Montpellier, CNRS, ENSCM, Montpellier, France
E-mail: nadir.bettache@umontpellier.fr, sebastien.ulrich@cnrs.fr

b Centro Singular de Investigacíon en Química Biolóxica e Materiais Moleculares (CIQUS), Departamento de Química Orgánica, Universidade de Santiago de Compostela, Santiago de Compostela, Spain

Abstract

Messenger RNA is a novel therapeutic modality which was key in curbing the Covid-19 pandemic. However, the delivery of mRNA in cells requires the development of smart vectors. We here report on amphiphilic dynamic covalent polymers formed in situ through RNA templating, and show effective nanoparticle formation and delivery of EGFP mRNA in cells.

Graphical abstract: mRNA delivery with templated dynamic covalent polymers

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Article information

DOI
https://doi.org/10.1039/D4CC06518B
Article type
Communication
Submitted
11 Dec 2024
Accepted
07 Feb 2025
First published
07 Feb 2025

Chem. Commun., 2025, Advance Article

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mRNA delivery with templated dynamic covalent polymers

J. G. Coll, L. M. A. Ali, J. Montenegro, N. Bettache and S. Ulrich, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D4CC06518B

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