DBU-promoted cascade phosphorylation/cyclization for the synthesis of phosphorylated 3-aminoindoles

Abstract

DBU-promoted cascade phosphorylation/cyclization for the synthesis of phosphorylated 3-aminoindoles A novel strategy of cascade phosphorylation cyclization of 2-isocyanobenzonitrile with phosphine oxide via DBU promoted process has been developed. A series of phosphorylated 3-aminoindoles were constructed by forming C–C, C–P, N–P bonds and an amino group in one pot. A plausible reaction mechanism has been proposed based on step-by-step control experiments and 31P NMR analysis.