Anion transport in biologically relevant lipid mixtures†
Krystyna
Maslowska-Jarzyna, 
ab
Sarah
Rooijmans,
ac
Daniel A.
McNaughton,
a
William G.
Ryder,
d
Edward
York,
a
Moniek
Tromp
c
and
Philip A.
Gale
*a
ab
Sarah
Rooijmans,
ac
Daniel A.
McNaughton,
a
William G.
Ryder,
d
Edward
York,
a
Moniek
Tromp
c
and
Philip A.
Gale
*a
Abstract
A potent squaramide-based anion transporter was used to evaluate how vesicles prepared with tailored lipid compositions, which mimic organelle membranes, can impact transmembrane transport. Using HPTS and ISE assays, we show that the lipid environment and POPE flip-flop dynamics significantly influence transport efficiency.
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