From the journal:

Chemical Communications

Heme-catalyzed reduction of N-oxide and its application to sensing heme and hemoglobin via a chemiluminescent probe†

Pengfei Lei,‡a   Chen Chen,‡a   Xuehui Liu,b   Shuang Wang,a   Jing Li,b   Xiang Lvb  and  Chong-Jing Zhang ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Bioactive Substances and Functions of Natural Medicines and Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
E-mail: zhangchongjing@imm.ac.cn

b State Key Laboratory of Complex, Severe and Rare Diseases, Haihe Laboratory of Cell Ecosystem, Department of Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 5 Dong Dan San Tiao, Beijing, China

Abstract

Catalytic reactions are extensively employed to amplify detection signals. Here, we present the overlooked catalytic nature of the heme-mediated reduction of N-oxide and the use of this process to guide the development of a chemiluminescence-based probe (CCP-1). The probe showed, unprecedentedly, similar responses towards free heme and hemoglobin.

Graphical abstract: Heme-catalyzed reduction of N-oxide and its application to sensing heme and hemoglobin via a chemiluminescent probe

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Article information

DOI
https://doi.org/10.1039/D5CC02085A
Article type
Communication
Submitted
14 Apr 2025
Accepted
28 May 2025
First published
29 May 2025

Chem. Commun., 2025, Advance Article

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Heme-catalyzed reduction of N-oxide and its application to sensing heme and hemoglobin via a chemiluminescent probe

P. Lei, C. Chen, X. Liu, S. Wang, J. Li, X. Lv and C. Zhang, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC02085A

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