Sono- and mechanochemical dual syntheses of bio-relevant aryldiazenyl-substituted phosphine oxides/phosphonates via P(O)–H functionalisation

Abstract

We herein disclose a dual-synthetic approach involving sonochemical and mechanochemical strategies for diversely functionalised (E)-diaryl(aryldiazenyl)phosphine oxides/phosphonates. Both methods offer highly efficient, practical and straightforward alternative routes for accessing this important class of biologically promising phosphoramide derivatives containing phosphorus–nitrogen (P–N) bonds. Significant advantages of the newly developed methods include mild reaction conditions, avoidance of any catalysts and additives, shorter reaction times, good to excellent yields, broad substrate scope, gram-scale applicability, operational simplicity, low E-factors, and eco-friendliness.