Copper(i)-catalyzed coupling of alkynyl glycosides: synthesis of buta-1,3-diyne-linked disaccharides and dinucleosides

Abstract

Herein we report copper-catalyzed coupling of alkynyl glycosides facilitating the synthesis of buta-1,3-diyne-linked disaccharides. The reaction is characterized by mild conditions employing eco-friendly reagents, resulting in good yields of the desired products. This methodology exhibits significant functional group tolerance with broad substrate scope. Furthermore, we have successfully extended this approach to the synthesis of buta-1,3-diyne-linked dinucleosides.