The stereocontrolled total synthesis of (±)-halichonine B was achieved in 18 steps for the longest linear sequence. This synthesis features the stereoselective construction of a trans-fused dehydrodecalin framework containing three consecutive stereocenters through sequential intramolecular conjugate additions. Additionally, the strategic use of nitrobenzenesulfonamides enabled the efficient installation of a branched diamine moiety.
F. Yoshimura, M. Uchida, K. Aratame, H. Ouchi, M. Inai, M. Kondo, R. TAKITA and T. Kan, Org. Biomol. Chem., 2025, Accepted Manuscript , DOI: 10.1039/D5OB00145E
To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.
If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.
If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.
Read more about how to correctly acknowledge RSC content.
Please wait while we load your content...
