Chiral Brønsted acid-catalyzed intermolecular hydrophenoxylation of ynamides with biaryl phenols via sequential desymmetrization/kinetic resolution

Abstract

Herein we disclose the first catalytic asymmetric intermolecular hydrophenoxylation of ynamides with biaryl phenols under chiral Brønsted acid catalysis, providing axially chiral phenols. This enantioselective reaction proceeds through a sequential desymmetrizaiton/kinetic resolution process, which features mild reaction conditions and represents a rare paradigm of an organocatalytic asymmetric intermolecular reaction of ynamides.