Site-selective C(sp3)–H amination of (het)aryl acetic acid derivatives under copper(ii) catalysis

Abstract

A ubiquitous copper(II) catalyzed cross-dehydrogenative (CDC) process of (Het)arylacetamide derivatives employing free cyclic/acyclic secondary amines with the aid of 8-aminoimidazo[1,2-a pyridine] (8-AIP) as a bidentate chelating auxiliary has been successfully developed. This methodology exhibits a broad substrate scope with good functional group compatibility in the presence of air. Furthermore, the synthetic adaptability of this novel protocol is showcased through the post-diversification of synthesized derivatives.