Palladium-catalyzed hydrocarbonylative cross-coupling with two different alkenes

Abstract

Transition metal-catalyzed hydrocarbonylation of alkenes has been widely studied; however, the hydrocarbonylation reaction that took place between two alkenes has been largely unexplored. Herein, we report a palladium-catalyzed hydrocarbonylative cross-coupling reaction with two different alkenes to produce structurally diverse β-ketoaldehyde surrogates, which can be easily converted to different types of heterocycles including pyrazole, isoxazole and pyrimidine.