Divergent application of 5-amino-isoxazoles for the construction of nitrogen heterocycles via the hydride transfer strategy

Abstract

The hydride transfer-enabled divergent application of 5-amino-isoxazoles for the controllable construction of diverse tetrahydroquinolines and tetrahydroquinazolines was disclosed unprecedentedly by the process of ring-cleavage/Beckmann rearrangement, dearomative-spirocyclization, or N,N′-dialkylation of the amino group with the employment of different Lewis acids.