Organic photoredox catalyst induced divergent transformations of o-halogenated benzamides

Abstract

The development of powerful reducing organic photoredox catalysts has recently opened wide avenues to activate strong carbon–halide bonds. Herein, we demonstrate divergent transformations of aryl radicals through visible-light-induced carbon–halide bond activation, enabling chemodivergent desaturation, radical cyclization, and radical ipso-substitution for the synthesis of enamides, isoindolinones, and biaryls. This catalytic system operates under mild conditions using 10-aryl-10H-phenothiazine, an easy-to-prepare organic photocatalyst, at room temperature.