Nanozyme-mediated high-entropy-driven photothermally enhanced tumor catalytic therapy

Abstract

Nanozyme-mediated catalytic therapy has emerged as a promising strategy for antitumor treatment, but it is imperative to further improve the catalytic efficiency of nanozymes to achieve potentiated antitumor efficacy. Single-phase high-entropy (HE) nanozymes with desirable enzyme-like catalytic activity and photothermal properties are appealing for enhancing the efficacy of catalytic therapy but have remained synthetically challenging. As a proof-of-concept demonstration, we herein prepared a single-phase HE Prussian blue analogue (HEPBA) using a conventional coprecipitation method. The HE mixing state enabled an exceptionally high photothermal conversion efficiency of 95.3% and a notable photothermally enhanced peroxidase-like catalytic activity. Therefore, the HEPBA-mediated photothermally enhanced catalytic therapy led to potentiated antitumor efficacy in both 4T1 and CT26 tumor-bearing mouse models. Thus, this work provides a rational and flexible platform for convenient and green preparation of biocompatible HE nanozymes and offers new perspectives on the use of HE nanozymes to improve the efficacy of catalytic therapy.

Graphical abstract: Nanozyme-mediated high-entropy-driven photothermally enhanced tumor catalytic therapy

Supplementary files

Article information

Article type
Paper
Submitted
14 Mar 2025
Accepted
23 May 2025
First published
04 Jun 2025

J. Mater. Chem. B, 2025, Advance Article

Nanozyme-mediated high-entropy-driven photothermally enhanced tumor catalytic therapy

Y. Xing, C. Yin, Y. Yin, J. Xue, Y. Liu, J. Li, L. Chi and W. Gu, J. Mater. Chem. B, 2025, Advance Article , DOI: 10.1039/D5TB00578G

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