Molecular medicine and cancer
Guest editors Heather M. Wallace, Paul J. Hergenrother and Peter J. Sadler introduce the Molecular Medicine and Cancer issue of Chemical Society Reviews
The challenges for cancer chemoprevention
The incidence of cancer is rising in parallel with an ageing populous thus increasing the strain on both treatment options and budgets for healthcare providers worldwide. Agents which can prevent cancers are therefore needed as a therapeutic alternative.
Ferrocifen type anti cancer drugs
The mechanisms of action of ferrocifens depend on several features: chemical structures, used concentrations, nature of cancer cells.
Chemical biology of anticancer gold(III) and gold(I) complexes
Anticancer gold complexes, including their mechanisms of action and the approaches adopted to improve the anticancer efficiency are described.
Linking the future of anticancer metal-complexes to the therapy of tumour metastases
Cancer chemotherapy is almost always applied to patients with one or more diagnosed metastases and is expected to impact these lesions, thus providing significant benefits to the patient.
Multi-platinum anti-cancer agents. Substitution-inert compounds for tumor selectivity and new targets
Substitution-inert polynuclear platinum complexes are inherently dual-function anti-cancer agents combining extra and intra-cellular effects in one structural chemotype.
About this collection
Guest edited by Peter Sadler, Heather Wallace and Paul Hergenrother, this themed issue on molecular medicine and cancer explores the impact of chemistry on recent developments in cancer therapy and the prospects for future step-changes. Consisting of a series of invited reviews from prominent scientists working in all aspects of molecular medicine and cancer therapy, this themed issues demonstrates recent progress in several directions within the field.