Themed collection Mass Spectrometry Metabolomics in Natural Products Research

5 items
Open Access Viewpoint

Illuminating the dark space of bioactive peptides with mass spectrometry

With emerging resistance and a lag in the development of new molecules, bioactive natural product peptides are a source of new chemistries to drive advances in medicine and biotechnology.

Graphical abstract: Illuminating the dark space of bioactive peptides with mass spectrometry
Open Access Highlight

Unlocking hidden treasures: the evolution of high-throughput mass spectrometry in screening for cryptic natural products

Natural products have traditionally been discovered one molecule at a time. Here we describe new innovations in the acquisition and analysis of mass spectrometry data that now enable metabolomics-guided high-throughput natural product discovery.

Graphical abstract: Unlocking hidden treasures: the evolution of high-throughput mass spectrometry in screening for cryptic natural products
Open Access Review Article

‘Need for speed: high throughput’ – mass spectrometry approaches for high-throughput directed evolution screening of natural product enzymes

In this review we highlight recent advancements in mass spectrometry that have allowed for more efficient, robust, and rigorous enzyme engineering for various applications relating to natural products chemistry.

Graphical abstract: ‘Need for speed: high throughput’ – mass spectrometry approaches for high-throughput directed evolution screening of natural product enzymes
Open Access Review Article

Describing the complex chemistry of benthic seawater: from exometabolite sampling strategies to MS-based metabolomics

This review highlights advances in characterizing exometabolites (EMs) from benthic organisms, starting with in situ sampling methods, then discussing how marine MS-based (exo)metabolomics benefits various fields while addressing ongoing challenges.

Graphical abstract: Describing the complex chemistry of benthic seawater: from exometabolite sampling strategies to MS-based metabolomics
Open Access Review Article

Effective data visualization strategies in untargeted metabolomics

Untargeted metabolomics faces researchers with complex processing, analysis, and interpretation tasks. Here, we review computational tools from the perspective of information visualization and underpin its critical role and importance to the field.

Graphical abstract: Effective data visualization strategies in untargeted metabolomics
5 items

About this collection

This collection, guest edited by Mehdi Beniddir, Nadja Cech, Neha Garg and Roger Linington, is dedicated to exploring the new developments that have been enabled by the application of mass spectrometry metabolomics to the natural product sciences, and to identifying both new strategies and best practices for the field.

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