Themed collection Nanomedicines for crossing biological barriers

Payload delivery systems for DNA- and RNA-based therapies are advancing with viral and non-viral vectors, including lipidic and polymeric nanoparticles. This work highlights their role in oncology, innovations, and use in clinical trials.

Schematic illustration of H₂Ti₃O₇ nanotube synthesis and Dox loading for targeted anti-glioma therapy applications. (Created in BioRender. Choudhury, S. (2025) https://BioRender.com/e3j13qm).

Five different nanocarrier lipid systems (NLSs) were developed and tested for mechanical properties, glioblastoma cell uptake, and blood-brain barrier transport, showing potential for brain drug and gene delivery.

Chemometric optimization of nitric oxide-releasing chitosan nanoparticles enabled enhanced stability, sustained NO delivery, and increased intracellular S-nitrosylation for skin-related biomedical therapies.

Atomically precise gold nanoclusters (AuNCs) are nanomolecular species with unique optoelectronic properties, both at the individual and assembled levels.

Magnetic resonance imaging and two-photon intravital microscopy metrics were correlated to track Ferumoxytol-based theranostic nanoparticles targeting glioblastoma multiforme in vivo at both macroscopic and microscopic levels.

A nanoplatform was designed to vectorize a ferrocifen drug: two amphiphilic prodrugs were co-nanoprecipitated. These self-assemblies demonstrated to slow down significantly the lung tumor volume in mice, after a pulmonary administration.