Themed collection 2025 Nanoscale HOT Article Collection

Biomimetic ion channels with subnanometer sizes for ion sieving: a mini-review
The ion-selective transport property of biological systems has inspired the development of biomimetic ion channels. This mini-review highlights the mechanisms, recent fabrication strategies and applications of biomimetic ion channels.
Nanoscale, 2025,17, 9021-9039
https://doi.org/10.1039/D5NR00758E
Recent advances in multimodal mechanoluminescent sensors enabled by nanostructure design
Multifunctional coupling and signal decoupling achieved through nanostructure and supramolecule design, enable multimodal mechanoluminescent materials to play an increasingly important role in interdisciplinary applications and cutting-edge fields.
Nanoscale, 2025,17, 6414-6426
https://doi.org/10.1039/D4NR04875J
Inspiration of Plant-Related Adhesion for Plant Wearable Sensor Interface Design
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D5NR00359H
2D monolayer electrocatalysts for CO2 electroreduction
Through bridging the gap between 2D material and single-atom material, 2D monolayer materials exhibit great potential in CO2RR due to their unique structural/electronic properties, high atom utilization and low mass transfer resistance.
Nanoscale, 2025,17, 4212-4225
https://doi.org/10.1039/D4NR04109G
Recent advances in mRNA-based therapeutics for neurodegenerative diseases and brain tumors
mRNA-based therapeutics have entered the mainstream with seemingly limitless possibilities to treat neurodegenerative diseases and brain tumors.
Nanoscale, 2025,17, 3537-3548
https://doi.org/10.1039/D4NR04394D
Mechanical and electromechanical properties of 2D materials studied via in situ microscopy techniques
This review summarizes recent advancements in in situ microscopy techniques applied to the study of mechanical and electromechanical properties of 2D materials. The latest results, corresponding challenges and future opportunities are discussed.
Nanoscale, 2025,17, 1722-1763
https://doi.org/10.1039/D4NR03569K
From synthesis to chiroptical activities: advancements in circularly polarized luminescent inorganic quantum dots
Review of synthesis strategies for circularly polarized luminescence (CPL) inorganic quantum dots, influencing factors, theoretical insight into CPL mechanisms, and future applications/prospects. Images reproduced with permission, details in article.
Nanoscale, 2025,17, 158-186
https://doi.org/10.1039/D4NR03600J
Co-reduction coupling of bicarbonate and nitrate toward efficient urea synthesis
The spatial charge region is rationally designed by constructing a Mott–Schottky heterostructure in the Cu-WN catalyst, achieving accurate activation of NO3− and HCO3− to accelerate the targeted electrochemical C–N coupling reaction.
Nanoscale, 2025,17, 9086-9093
https://doi.org/10.1039/D4NR05196C
Lorentz force-assisted growth of romanesco-like Ni–Fe nano-cone arrays for enhanced oxygen evolution reaction at high current densities
A novel Lorentz-force-assisted electrodeposition method is introduced to fabricate Romanesco-like Ni–Fe nano-cone arrays with enhanced stability and efficient bubble release for the oxygen evolution reaction (OER) under high current densities.
Nanoscale, 2025,17, 8466-8475
https://doi.org/10.1039/D4NR05174B

Strong and reciprocal magneto-phonon effects in a 2D antiferromagnetic semiconductor FePSe3
Magnon–phonon coupling and spin-phonon interaction are interplays between phonons and magnetism, offering new approaches to manipulate phonons related to magnetism.
Nanoscale, 2025,17, 8476-8483
https://doi.org/10.1039/D4NR04743E
Self-assembled colloidal glass with 100% lanthanide nanocrystal loading for high-resolution X-ray imaging
A new class of bright, transparent colloidal glasses with 100% nanoparticle loading was developed via self-assembly, addressing the longstanding trade-offs between optical transparency and scintillation efficiency in X-ray imaging technology.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR05213G
Programming a multiplex lanthanide nanoparticle for customized cancer treatment with real-time efficiency feedback
Customized cancer therapy relies on timely therapeutic effect evaluation to provide prescription adjustment for individual cases.
Nanoscale, 2025,17, 9184-9196
https://doi.org/10.1039/D5NR00390C
Unraveling the infrared detection properties of Bi2Te3 depending on thickness under the semiconductor and metal surface states
As the thickness of the Bi2Te3 film increases, its photoelectric response mechanism changes from a photoconductive effect to a photobolometric effect.
Nanoscale, 2025,17, 8524-8532
https://doi.org/10.1039/D4NR05067C
Formation of electron-deficient Ni in a Nb/NiFe-layered double hydroxide nanoarray via electrochemical activation for efficient water oxidation
The Nb/NiFe-LDH nanoarray material was successfully synthesized, which has high-efficiency alkaline oxygen evolution activity.
Nanoscale, 2025,17, 7825-7829
https://doi.org/10.1039/D4NR05492J
Halogen anion modulated metal–organic frameworks with enhanced nanozyme activities for bacterial biofilm disruption
A schematic illustration of the breakage of S. aureus biofilms with chloroquine-promoted transformation of Z-eDNA to B-eDNA, and bacteria elimination by reactive oxygen species (ROS) due to ZIF-L-H-Cl oxidase-like activities.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR00131E
Densely distributed Co onto carbon-layer-coated flower-like Ni/Al2O3 and its tailored integration into a stirrer for multiple catalytic degradation and solar-powered water evaporation
Multiple functional tailored materials have shown great potential for both pollutant degradation and freshwater recovery.
Nanoscale, 2025,17, 7076-7090
https://doi.org/10.1039/D4NR04430D

Landé g-factors of electrons and holes strongly confined in CsPbI3 perovskite nanocrystals in glass
The Landé g-factor of charge carriers is a key parameter in spin physics controlling spin polarization and spin dynamics.
Nanoscale, 2025,17, 6522-6529
https://doi.org/10.1039/D4NR04602A
Epoxy-based vitrimeric semi-interpenetrating network/MXene nanocomposites for hydrogen gas barrier applications
The H2 gas-barrier performance of a nylon 6 substrate is improved by an MXene-reinforced semi-interpenetrating network comprised of a poly(ethylene-co-vinyl alcohol)/epoxy vitrimer nanocomposite with the added feature of self-healing characteristics.
Nanoscale, 2025,17, 5755-5769
https://doi.org/10.1039/D4NR04702H

Unique NiCo bimetal boosting 98% CH4 selectivity and high catalysis stability for photothermal CO2 hydrogenation
This paper reveals the synergistic and complementary roles of light and heat in photothermal catalysis on NiCo alloy catalysts. The catalyst exhibits high CH4 selectivity and catalytic stability in the photothermal CO2 hydrogenation reaction.
Nanoscale, 2025,17, 5770-5777
https://doi.org/10.1039/D4NR05471G
Mn(II)-MOF nanoparticles conjugated with EOB-PEG as high-performance hepatobiliary-specific MRI contrast agents
Hepatobiliary magnetic resonance imaging (MRI) is a crucial diagnostic tool for early detection and staging of liver tumors.
Nanoscale, 2025,17, 5743-5754
https://doi.org/10.1039/D4NR05293E

Doping Gd16 nanoclusters for expanded optical properties and thermometry applications
We achieved green–red color-tunable luminescence by controlling the doping of Tb3+ and Eu3+ ions in Gd16 clusters and attained a high relative sensitivity of up to 4.6% K−1 in the as-doped Gd15Tb1−xEux (x = 0.8).
Nanoscale, 2025,17, 5074-5080
https://doi.org/10.1039/D4NR04779F
Defect passivation engineering of chalcogenide quantum dots via in situ fluorination treatment
Efficient carrier transport through reducing the traps in chalcogenide quantum dots (QDs) is crucial for their application in optoelectronic devices.
Nanoscale, 2025,17, 5064-5073
https://doi.org/10.1039/D4NR04410J
Constructing fecal-derived electrocatalysts for CO2 upcycling: simultaneously tackling waste and carbon emissions
We developed a Cu-based electrocatalyst from pig manure-derived biochar for efficient CO2 reduction, achieving 87.14% faradaic efficiency and 44.80% multicarbon product selectivity.
Nanoscale, 2025,17, 5056-5063
https://doi.org/10.1039/D4NR04943H
Heteroatom number-dependent cluster frameworks in structurally comparable Pd–Au nanoclusters
This work achieved the manipulation of Pd dopant numbers in the cluster framework based on two structurally comparable PdxAu12 (x = 1, 2) nanoclusters.
Nanoscale, 2025,17, 4494-4501
https://doi.org/10.1039/D4NR05222F
A Ni2P/NiMoOx nanocone electrocatalyst for efficient hydrogen evolution: tip-enhanced local electric field effect
Ni2P/NiMoOx nanocones can effectively enhance the electrocatalytic hydrogen evolution reaction through a cross-scale synergistic effect of the mesoscale local electric field and the atomic scale electron structure.
Nanoscale, 2025,17, 4485-4493
https://doi.org/10.1039/D4NR05221H
High-performance van der Waals stacked transistors based on ultrathin GaPS4 dielectrics
The layered wide bandgap semiconductor gallium thiophosphate can be applied as a gate dielectric to achieve high-performance Van der Waals field-effect transistors.
Nanoscale, 2025,17, 4465-4471
https://doi.org/10.1039/D4NR03685A

Eco-friendly synthesis of a porous reduced graphene oxide–polypyrrole–gold nanoparticle hybrid nanocomposite for electrochemical detection of methotrexate using a strip sensor
Chemotherapy is a crucial cancer treatment, but its effectiveness requires precise monitoring of drug concentrations in patients.
Nanoscale, 2025,17, 4472-4484
https://doi.org/10.1039/D4NR04010D
Metal–organic framework-based nanoplatforms for synergistic anti-atherosclerosis therapy by regulating the PI3K/AKT/MSR1 pathway in macrophages
TPP was combined with ZIF-8, to construct ZIF-8@TPP, to treat atherosclerosis. This nanoplatform showed excellent anti-atherosclerotic effect in vivo mainly by inhibiting lipid phagocytosis of macrophages via downregulating the PI3K/AKT/MSR1 pathway.
Nanoscale, 2025,17, 3071-3085
https://doi.org/10.1039/D4NR04058A
White circularly polarized luminescence from a dual-component emitter induced by FRET between tetraphenylene and PDI derivatives
LHS with TPE-ASP as the chiral donor and PDI as the energy acceptor was constructed by electrostatic interaction, achieving 94.7% ΦET and glum up to |2.41 × 10−2|. Meanwhile, white CPL (0.32, 0.33) was modulated by these two components.
Nanoscale, 2025,17, 3086-3094
https://doi.org/10.1039/D4NR03598D

Detection and distinction of amino acids and post-translational modifications with gold nanojunctions
For single amino acid detection, we have investigated two different nano-devices based on gold electrodes.
Nanoscale, 2025,17, 2498-2505
https://doi.org/10.1039/D4NR03359K
Fabrication of a symmetric supercapacitor device using MnO2/cellulose nanocrystals/graphite electrodes via sputtering for energy storage
This work focuses on MnO2/CNCs/graphite hybrid electrodes with high capacitance and excellent cyclic retention for energy storage. MnO2 was deposited via RF magnetron sputtering to prepare the robust device.
Nanoscale, 2025,17, 1289-1307
https://doi.org/10.1039/D4NR03476G
A 3D mixed ion-electron conducting framework for dendrite-free lithium metal anodes
A mixed ion-electron conducting framework, LLTO@CNT, was designed for lithium metal batteries with uniform Li deposition and long cycling stability.
Nanoscale, 2025,17, 1282-1288
https://doi.org/10.1039/D4NR04455J

Machine learning-guided discovery of gas evolving electrode bubble inactivation
Experimental interrogation unveils that as much as 75% of the area underneath bubbles is electrochemically active. A simple method for estimating the degree of electrode inactivation due to bubbles is demonstrated.
Nanoscale, 2025,17, 1270-1281
https://doi.org/10.1039/D4NR02628D
Holey etching strategy of siloxene nanosheets to improve the rate performance of photo-assisted Li–O2 batteries
P-siloxene nanosheets used as cathode catalysts for photo-assisted Li–O2 batteries significantly improve the electrochemical performance of the devices.
Nanoscale, 2025,17, 243-251
https://doi.org/10.1039/D4NR03850A
Preceramic polymer-hybridized phenolic aerogels and the derived ZrC/SiC/C ceramic aerogels with ultrafine nanocrystallines
This work provides a facile approach to fabricate hybrid phenolic aerogels and derived ZrC/SiC/C ceramic aerogels, which target on applications for extreme environments in aerospace field.
Nanoscale, 2025,17, 230-242
https://doi.org/10.1039/D4NR03470H
About this collection
This ongoing web collection features all the articles published in Nanoscale in 2025 that have been highlighted as HOT by our reviewers. Congratulations to all the authors whose articles are featured!