Reverse-hydroformylation: a missing reaction explored
Recent progress in transition-metal catalysed acceptor- and acceptorless-reverse hydroformylation of aldehydes for the conversion of olefins has been discussed. The aldehyde feedstock serves as a source for production of syngas and valuable alkenes.
Engineering ligands on the Au center: discovering broadly applicable gold catalysis with high turnover numbers
The research groups of Hammond/Xu and Zhang report the discovery of new ligands for gold catalysis.
Chromium-catalyzed transformations with Grignard reagents – new opportunities for cross-coupling reactions
Recent advances in chromium-catalyzed cross-couplings of C–X and C–H bonds with Grignard reagents are highlighted.
The quest for observation and isolation of oxyallyl derivatives
This review summarizes 50 years of attempts to observe, and finally isolate, the elusive oxyallyl derivatives.
Metalorganocatalysis: cooperating transition-metal catalysis and organocatalysis through a covalent bond
Asymmetric catalysis has grown rapidly and made considerable progress in the last few decades, but there still remain significantly unachievable reactions through either organocatalysis or transition-metal catalysis alone.
Transition metal-catalyzed C–H bond functionalizations by the use of diverse directing groups
In this review, a summary of transition metal-catalyzed C–H activation by utilizing the functionalities as directing groups is presented.
Catalysis by electrons and holes: formal potential scales and preparative organic electrochemistry
The present review surveys current chemical understanding of catalysis by addition and removal of an electron.
Catalytic asymmetric synthesis of polysubstituted spirocyclopropyl oxindoles: organocatalysis versus transition metal catalysis
Recent progress in catalytic asymmetric synthesis of spirocyclopropyl oxindoles via organocatalysis and transition metal catalysis are summarized and discussed.
The Mitsunobu reaction in the 21st century
Recent advancements in the condensation of alcohols with pronucleophiles by the Mitsunobu reaction are described.
Silylative coupling of olefins with vinylsilanes in the synthesis of functionalized alkenes
Recent developments in the sequential synthetic strategies including ruthenium-catalyzed silylative coupling followed by desilylation, leading to π-conjugated organic derivatives are presented.
Handling diazonium salts in flow for organic and material chemistry
Diazonium salts and flow chemistry are the perfect wedding for a safe handling.
Negishi coupling in the synthesis of advanced electronic, optical, electrochemical, and magnetic materials
Negishi coupling is an efficient and versatile tool for selective C–C bond formation in the synthesis of organic electronic, optical, electrochemical, and magnetic materials.
Novel strategies for catalytic asymmetric synthesis of C1-chiral 1,2,3,4-tetrahydroisoquinolines and 3,4-dihydrotetrahydroisoquinolines
This review summarizes recent progress in catalytic asymmetric construction of 1,2,3,4-tetrahydroisoquinolines and 3,4-dihydroisoquinolines, among the most important “privileged scaffolds”.
Catalytic enantioselective organic transformations via visible light photocatalysis
Enantioselective transformations via visible light photocatalysis are discussed and could have a strong impact on asymmetric photoreactions.
Transition metal-catalyzed direct remote C–H functionalization of alkyl groups via C(sp3)–H bond activation
This review is focused on the recent advances in the transition metal-catalyzed direct remote C–H-functionalization of alkyl groups via C(sp3)–H bond activation. In general, carboxamide/ester-chelated β-functionalization reactions are summarized.
Recent applications of chiral N-tert-butanesulfinyl imines, chiral diene ligands and chiral sulfur–olefin ligands in asymmetric synthesis
The highly efficient asymmetric reactions of chiral sulfinyl auxiliary, diene ligands and sulfur–olefin ligands are presented.
About this collection
Review-type articles published by Organic Chemistry Frontiers in 2015 are collated as below for the benefit of readers.