Synthesis of chiral N-free sulfinamides by asymmetric condensation of stable sulfinates and ammonium salts

Abstract

Herein, we developed a practical approach using stable, cost-effective ammonium salts with an organic base to generate anhydrous ammonia for asymmetric sulfinylation, achieving a broad range of enantioenriched sulfinamides with excellent yields and optical purity. Additionally, these sulfinamide products serve as versatile precursors for S-stereogenic functional molecules with potential in organic synthesis and drug discovery.