Issue 12, 2017

Synthetic strategies towards mycolactone A/B, an exotoxin secreted by Mycobacterium ulcerans

Abstract

Mycolactone A/B, a complex polyketidic macrolide secreted by Mycobacterium ulcerans, has been synthesized using catalytic and/or asymmetric reactions. Several palladium-catalyzed reactions were investigated for forging key σ-bonds as well as a particularly challenging hydroboration reaction of a functionalized and sterically demanding 1,1-disubstituted exo-alkene. The full account of these investigations is discussed.

Graphical abstract: Synthetic strategies towards mycolactone A/B, an exotoxin secreted by Mycobacterium ulcerans

Supplementary files

Article information

Article type
Research Article
Submitted
20 יול 2017
Accepted
25 אוג 2017
First published
28 אוג 2017

Org. Chem. Front., 2017,4, 2380-2386

Synthetic strategies towards mycolactone A/B, an exotoxin secreted by Mycobacterium ulcerans

S. Saint-Auret, H. Abdelkafi, D. Le Nouen, P. Bisseret and N. Blanchard, Org. Chem. Front., 2017, 4, 2380 DOI: 10.1039/C7QO00608J

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