Issue 23, 2016

A biodegradable, biocompatible transdermal device derived from carboxymethyl cellulose and multi-walled carbon nanotubes for sustained release of diclofenac sodium

Abstract

A hybrid nanocomposite hydrogel (CMC–MWCNT) has been fabricated using carboxymethyl cellulose (CMC) and acid-functionalized multi-walled carbon nanotubes (MWCNTs) at room temperature for transdermal delivery of diclofenac sodium. With variation of MWCNT concentration, various grades of nanocomposites have been prepared and an optimized composite (CMC–MWCNT 3) has been considered with lower % swelling and higher gel strength. The synthesized nanocomposite has been characterized using FTIR spectroscopy, FESEM, TGA, AFM and TEM analyses. The gel strength of the nanocomposites has been measured by determining the rheological parameters. The biodegradability of the composite material has been confirmed using lysozyme hydrochloride. A biocompatibility study using primary rat fibroblasts (RFBs) confirmed the non-cytotoxic nature of the composite. The release profiles of diclofenac sodium indicate that the synthesized composite releases the drug in a sustained manner and would be a better alternative for transdermal devices.

Graphical abstract: A biodegradable, biocompatible transdermal device derived from carboxymethyl cellulose and multi-walled carbon nanotubes for sustained release of diclofenac sodium

Supplementary files

Article information

Article type
Paper
Submitted
05 ינו 2016
Accepted
08 פבר 2016
First published
09 פבר 2016

RSC Adv., 2016,6, 19605-19611

A biodegradable, biocompatible transdermal device derived from carboxymethyl cellulose and multi-walled carbon nanotubes for sustained release of diclofenac sodium

B. Mandal, D. Das, A. P. Rameshbabu, S. Dhara and S. Pal, RSC Adv., 2016, 6, 19605 DOI: 10.1039/C6RA00260A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements