Issue 9, 2018

Catalyst-controlled synthesis of 4-amino-isoquinolin-1(2H)-one and oxazole derivatives

Abstract

A facile synthetic method to access 4-amino-isoquinolin-1(2H)-one and oxazole derivatives was disclosed in this paper. The reaction of N-(pivaloyloxy)-amides with ynamides produced 4-amino-isoquinolin-1(2H)-ones in good yields in the presence of Cp*Rh(III) catalyst through a C–H bond functionalization. Using Sc(OTf)3 as the catalyst, oxazole derivatives were obtained in good yields from the same reaction. This protocol features good functional group tolerance and excellent regioselectivity.

Graphical abstract: Catalyst-controlled synthesis of 4-amino-isoquinolin-1(2H)-one and oxazole derivatives

Supplementary files

Article information

Article type
Research Article
Submitted
03 פבר 2018
Accepted
05 מרץ 2018
First published
08 מרץ 2018

Org. Chem. Front., 2018,5, 1466-1470

Catalyst-controlled synthesis of 4-amino-isoquinolin-1(2H)-one and oxazole derivatives

B. Niu, R. Liu, Y. Wei and M. Shi, Org. Chem. Front., 2018, 5, 1466 DOI: 10.1039/C8QO00125A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements