Issue 11, 2019

Nickel-catalyzed anti-Markovnikov hydroarylation of alkenes

Abstract

We have developed a nickel-catalyzed hydroarylation of alkenes using aryl halides as coupling partners. Excellent anti-Markovnikov selectivity is achieved with aryl-substituted alkenes and enol ethers. We also show that hydroarylation occurs with alkyl substituted alkenes to yield linear products. Preliminary examination of the reaction mechanism suggests irreversible hydrometallation as the selectivity determining step of the hydroarylation.

Graphical abstract: Nickel-catalyzed anti-Markovnikov hydroarylation of alkenes

Supplementary files

Article information

Article type
Edge Article
Submitted
06 דצמ 2018
Accepted
03 פבר 2019
First published
13 פבר 2019
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2019,10, 3231-3236

Nickel-catalyzed anti-Markovnikov hydroarylation of alkenes

J. Nguyen, A. Chong and G. Lalic, Chem. Sci., 2019, 10, 3231 DOI: 10.1039/C8SC05445B

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements