Issue 41, 2023

Bismuth nanoclusters on nitrogen-doped porous carbon nanoenzyme for cancer therapy

Abstract

Among the emerging cancer therapeutic methods, nanocatalytic therapy through the rational design of nanozymes is considered to be a promising strategy. However, high-performance nanozymes with the ability to catalyze the production of toxic substances to efficiently kill cancer cells are still highly desired. Herein, we fabricate bismuth nanoclusters loaded on nitrogen-doped porous carbon (Bi-NC) as a nanozyme for cancer therapy. The Bi-NC nanozyme displays both peroxidase (POD) and glutathione oxidase (GSHOx) biomimetic enzymatic activities, especially in a tumor microenvironment (TME), which catalyzes the production of hydroxyl radicals (·OH) and depletes antioxidant glutathione (GSH), simultaneously. Moreover, Bi-NC exhibits good photothermal conversion performance under near-infrared light irradiation. After surface modification with hyaluronic acid (HA) to improve the dispersity of nanoparticles and their accumulation in tumor tissues, Bi-NC@HA exhibits remarkable antitumor effects through the synergistic effect of catalytic and photothermal therapy. This work provides a new pathway for designing high-performance nanozymes for cancer catalytic therapy.

Graphical abstract: Bismuth nanoclusters on nitrogen-doped porous carbon nanoenzyme for cancer therapy

Supplementary files

Article information

Article type
Paper
Submitted
08 אוג 2023
Accepted
21 ספט 2023
First published
09 אוק 2023

Nanoscale, 2023,15, 16619-16625

Bismuth nanoclusters on nitrogen-doped porous carbon nanoenzyme for cancer therapy

S. Zhong, Z. Zhang, Y. Zhao, S. Wang, Q. Hu and L. Li, Nanoscale, 2023, 15, 16619 DOI: 10.1039/D3NR03957A

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