Concise asymmetric total synthesis of (−)-patchouli alcohol†
Abstract
The asymmetric total synthesis of (−)-patchouli alcohol was accomplished in a concise manner. Key reactions include a highly diastereo- and enantioselective formal organocatalytic [4 + 2] cycloaddition reaction, a radical denitration reaction, and an oxidative carboxylation reaction. The formal synthesis of norpatchoulenol was achieved as well.
- This article is part of the themed collections: Celebrating 70 Years of Shanghai Institute of Organic Chemistry, Synthetic Approaches to Natural Products via Catalytic Processes and Organic Chemistry Frontiers HOT articles for 2017
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