Issue 2, 2022

Molecular probes for cellular imaging of post-translational proteoforms

Abstract

Specific post-translational modification (PTM) states of a protein affect its property and function; understanding their dynamics in cells would provide deep insight into diverse signaling pathways and biological processes. However, it is not trivial to visualize post-translational modifications in a protein- and site-specific manner, especially in a living-cell context. Herein, we review recent advances in the development of molecular imaging tools to detect diverse classes of post-translational proteoforms in individual cells, and their applications in studying precise roles of PTMs in regulating the function of cellular proteins.

Graphical abstract: Molecular probes for cellular imaging of post-translational proteoforms

Article information

Article type
Review Article
Submitted
29 sep. 2021
Accepted
04 jan. 2022
First published
04 jan. 2022
This article is Open Access
Creative Commons BY license

RSC Chem. Biol., 2022,3, 201-219

Molecular probes for cellular imaging of post-translational proteoforms

S. Suraritdechachai, B. Lakkanasirorat and C. Uttamapinant, RSC Chem. Biol., 2022, 3, 201 DOI: 10.1039/D1CB00190F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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