Qingyao Zhang, Cankun Luo, Ruizhi Lai, Zhiqian Lin, Pengfei Jia, Shuran Xu, Li Guo and Yong Wu
Green Chem., 2023,25, 7068-7072
DOI:
10.1039/D3GC02683C,
Communication
A new strategy for direct access to unreported α-cyanato-α′-carbonyl sulfoxonium ylides is reported. The developed open-flask operation is a catalyst-, metal- and additive-free green process, which has good compatibility with various substituents and generally excellent yields. This protocol can be applied to gram-scale production and modification of bioactive drugs which demonstrate the practicality of this method.
