Issue 35, 2023

Platinum-based nanodendrites as glucose oxidase-mimicking surrogates

Abstract

Catalytic conversion of glucose represents an interesting field of research with multiple applications. From the biotechnology point of view, glucose conversion leads to the fabrication of different added-value by-products. In the field of nanocatalytic medicine, the reduction of glucose levels within the tumor microenvironment (TME) represents an appealing approach based on the starvation of cancer cells. Glucose typically achieves high conversion rates with the aid of glucose oxidase (GOx) enzymes or by fermentation. GOx is subjected to degradation, possesses poor recyclability and operates under very specific reaction conditions. Gold-based materials have been typically explored as inorganic catalytic alternatives to GOx in order to convert glucose into building block chemicals of interest. Still, the lack of sufficient selectivity towards certain products such as gluconolactone, the requirement of high fluxes of oxygen or the critical size dependency hinder their full potential, especially in liquid phase reactions. The present work describes the synthesis of platinum-based nanodendrites as novel enzyme-mimicking inorganic surrogates able to convert glucose into gluconolactone with outstanding selectivity values above 85%. We have also studied the enzymatic behavior of these Pt-based nanozymes using the Michaelis–Menten and Lineweaver–Burk models and used the main calculation approaches available in the literature to determine highly competitive glucose turnover rates for Pt or Pt–Au nanodendrites.

Graphical abstract: Platinum-based nanodendrites as glucose oxidase-mimicking surrogates

  • This article is part of the themed collection: Nanozymes

Supplementary files

Article information

Article type
Paper
Submitted
02 maí 2023
Accepted
29 júl. 2023
First published
01 ágú. 2023
This article is Open Access
Creative Commons BY-NC license

Nanoscale, 2023,15, 14399-14408

Platinum-based nanodendrites as glucose oxidase-mimicking surrogates

J. I. Garcia-Peiro, J. Bonet-Aleta, M. L. Tamayo-Fraile, J. L. Hueso and J. Santamaria, Nanoscale, 2023, 15, 14399 DOI: 10.1039/D3NR02026F

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