Issue 4, 2023

Base-promoted synthesis of tetrasubstituted alkenylboronates from propargyl amines and B2pin2via dual 1,4-metallate shift and B–N elimination

Abstract

An efficient approach to synthesize tetrasubstituted alkenylboronates via a cascade borylation/B–N elimination of propargyl amines and B2pin2 is disclosed. A series of tetrasubstituted alkenylboronates were readily furnished using this strategy in good yields. In addition, a series of derivatizations of the tetrasubstituted alkenylboronates were also well achieved.

Graphical abstract: Base-promoted synthesis of tetrasubstituted alkenylboronates from propargyl amines and B2pin2via dual 1,4-metallate shift and B–N elimination

Supplementary files

Article information

Article type
Research Article
Submitted
06 okt. 2022
Accepted
21 des. 2022
First published
22 des. 2022

Org. Chem. Front., 2023,10, 905-910

Base-promoted synthesis of tetrasubstituted alkenylboronates from propargyl amines and B2pin2via dual 1,4-metallate shift and B–N elimination

K. Liu, S. Jin and Q. Song, Org. Chem. Front., 2023, 10, 905 DOI: 10.1039/D2QO01576E

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