Asymmetric synthesis of chiral sp3-geminated borylstannyl, borylsilyl, and diboryl compounds

Abstract

In the past decades, chiral sp³-geminated bimetallic reagents based on B, Si, and Sn have drawn much attention due to their unique structure and the potential for iterative multifold transformations, thus efficiently increasing the molecular complexity. However, the asymmetric preparation of such reagents is highly challenging and new synthetic approaches are still in demand. This review provides a brief overview of the synthesis of nonracemic gem-borylstannyl, gem-borylsilyl, and gem-diboryl compounds, and is organized according to the types of gem-bimetallic reagents and their corresponding synthetic strategies.