William Doherty, Jinju James, Paul Evans, Laura Martin, Nikoletta Adler, Derek Nolan and Andrew Knox
Org. Biomol. Chem., 2014,12, 7561-7571
DOI:
10.1039/C4OB01412J,
Paper
An improved, Weinreb amide-based, synthesis of anti-trypanosomal lysine-containing vinyl sulfones is described incorporating, as a feature, diversity at the ε-lysine amino group. Members of this family demonstrated moderate to good efficacy as anti-trypanosomal agents and a fluorescent dansyl (19) derivative was used to investigate subcellular localisation of the compound class.
