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Described is a total synthesis of racemic mersicarpine from diethyl 4-oxopimelate. The synthetic route takes advantage of a 2-indolyl radical cyclization to construct the pyrido[1,2-a]indole scaffold bearing the all-carbon quaternary stereocenter.

Graphical abstract: Total synthesis of (±)-mersicarpine following a 6-exo-trig radical cyclization

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