Xing Zhou, Zhangbo Cui, Liquan Liu, Ziyong Sun, Meng Lin, Qingyi Hu, Hongbo Wang and Xianjin Xiao
Analyst, 2018,143, 2755-2759
DOI:
10.1039/C8AN00555A,
Communication
We have disclosed the unique inhibition effect of small molecule–protein interactions toward the DNA branch migration process and constructed a complete thermodynamic model for it. The disclosed effect was further coupled with the steric hindrance effect to establish a homogeneous assay for proteins and small molecules with ultra-high inhibition factors and sensitivity.
