Kanako Nozawa-Kumada, Kanako Ono, Satoshi Kurosu, Masanori Shigeno and Yoshinori Kondo
Org. Biomol. Chem., 2022,20, 5948-5952
DOI:
10.1039/D2OB00281G,
Communication
Herein, we describe the copper-catalyzed aerobic C(sp3)–H functionalization of 2-alkylbenzamides for the synthesis of benzolactones. This reaction proceeds via 1,5-hydrogen atom transfer of N-centered radicals directly generated by N–H bond cleavage and does not require the synthesis of pre-functionalized N-centered radical precursors or the use of strong stoichiometric oxidants.