Issue 18, 2013
From the journal:

Nanoscale

Nanostructure-induced DNA condensation

Ting Zhou,†ab   Axel Llizo,†ac   Chen Wang,a   Guiying Xu*b  and  Yanlian Yang*a  

* Corresponding authors

a National Center for Nanoscience and Technology (NCNST), Beijing 100190, P. R. China
E-mail: wangch@nanoctr.cn, yangyl@nanoctr.cn
Tel: +86 10 82545559

b Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, Shandong University, Jinan 250100, P. R. China
E-mail: xuguiying@sdu.edu.cn
Tel: +86 531 8836 5436

c Centro de Estudios Avanzados de Cuba, La Habana, Cuba

Abstract

The control of the DNA condensation process is essential for compaction of DNA in chromatin, as well as for biological applications such as nonviral gene therapy. This review endeavours to reflect the progress of investigations on DNA condensation effects of nanostructure-based condensing agents (such as nanoparticles, nanotubes, cationic polymer and peptide agents) observed by using atomic force microscopy (AFM) and other techniques. The environmental effects on structural characteristics of nanostructure-induced DNA condensates are also discussed.

Graphical abstract: Nanostructure-induced DNA condensation

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Article information

DOI
https://doi.org/10.1039/C3NR01630G
Article type
Review Article
Submitted
01 4 2013
Accepted
18 6 2013
First published
20 6 2013

Nanoscale, 2013,5, 8288-8306

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Nanostructure-induced DNA condensation

T. Zhou, A. Llizo, C. Wang, G. Xu and Y. Yang, Nanoscale, 2013, 5, 8288 DOI: 10.1039/C3NR01630G

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