Fluorescence imaging of hypochlorous acid and peroxynitrite in vitro and in vivo with emission wavelength beyond 750 nm

Linfang Wang; Jing Liu; Shengwei Zhao; Hongxing Zhang; Yuanqiang Sun; Aihua Wei; Wei Guo

doi:10.1039/D0CC02322A

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Fluorescence imaging of hypochlorous acid and peroxynitrite in vitro and in vivo with emission wavelength beyond 750 nm†

Linfang Wang,^a Jing Liu,*^a Shengwei Zhao,^b Hongxing Zhang,^a Yuanqiang Sun,^c Aihua Wei^d and Wei Guo

*^a

Author affiliations

* Corresponding authors

^a School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
E-mail: liujing4203@sxu.edu.cn, guow@sxu.edu.cn

^b School of Aerospace Engineering and Applied Mechanics, Tongji University, Shanghai 200092, China

^c College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001, P. R. China

^d Shanxi University Library, Shanxi University, Taiyuan 030006, China

Abstract

A series of near-infrared and photostable Si-oxazine fluorescent dyes was synthesized using a simple three-step procedure, and one of their reduced products, i.e. hydro-Si-oxazine HSiO3, has been utilized to sensitively detect hypochlorous acid and peroxynitrite generation by phagocytes in inflamed and pulmonary fibrosis diseased mice with emission wavelength beyond 750 nm.

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DOI: https://doi.org/10.1039/D0CC02322A
Article type: Communication
Submitted: 27 4 2020
Accepted: 05 6 2020
First published: 06 6 2020

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Chem. Commun., 2020,56, 7718-7721

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Fluorescence imaging of hypochlorous acid and peroxynitrite in vitro and in vivo with emission wavelength beyond 750 nm

L. Wang, J. Liu, S. Zhao, H. Zhang, Y. Sun, A. Wei and W. Guo, Chem. Commun., 2020, 56, 7718 DOI: 10.1039/D0CC02322A

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Chemical Communications

Fluorescence imaging of hypochlorous acid and peroxynitrite in vitro and in vivo with emission wavelength beyond 750 nm†

Abstract

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Fluorescence imaging of hypochlorous acid and peroxynitrite in vitro and in vivo with emission wavelength beyond 750 nm

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