Harsimran K. Minhas, William Riley, Alison M. Stuart and Martyna Urbonaite
Org. Biomol. Chem., 2018,16, 7170-7173
DOI:
10.1039/C8OB02236D,
Paper
Hexafluoroisopropan-2-ol (HFIP) is an excellent solvent for promoting fluorinations with the hypervalent fluoroiodane reagent 1 and crucially, it removes the need for transition metals or TREAT-HF activators. The fluoroiodane reagent 1 was used in HFIP to monofluorinate 1,3-ketoesters and to fluorocyclise unsaturated carboxylic acids in excellent yields under mild reaction conditions.
