Issue 5, 2021
From the journal:

RSC Chemical Biology

Squaric acid as a new chemoselective moiety for mass spectrometry-based metabolomics analysis of amines†

Weifeng Lin, ORCID logo a   Zhen Yang,a   Amanpreet Kaur, ORCID logo a   Annika Block,a   Miroslav Vujasinovic,b   J.-Matthias Löhrbc  and  Daniel Globisch ORCID logo *a  

* Corresponding authors

a Department of Chemistry–BMC, Science for Life Laboratory, Uppsala University, Box 599, Uppsala SE-75124, Sweden
E-mail: Daniel.globisch@scilifelab.uu.se

b Department for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden

c Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institute, Stockholm, Sweden

Abstract

The investigation of microbiome-derived metabolites is important to understand metabolic interactions with their human host. New methodologies for mass spectrometric discovery of undetected metabolites with unknown bioactivity are required. Herein, we introduce squaric acid as a new chemoselective moiety for amine metabolite analysis in human fecal samples.

Graphical abstract: Squaric acid as a new chemoselective moiety for mass spectrometry-based metabolomics analysis of amines

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Article information

DOI
https://doi.org/10.1039/D1CB00132A
Article type
Communication
Submitted
15 6 2021
Accepted
10 8 2021
First published
12 8 2021
This article is Open Access
Creative Commons BY-NC license

RSC Chem. Biol., 2021,2, 1479-1483

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Squaric acid as a new chemoselective moiety for mass spectrometry-based metabolomics analysis of amines

W. Lin, Z. Yang, A. Kaur, A. Block, M. Vujasinovic, J.-Matthias Löhr and D. Globisch, RSC Chem. Biol., 2021, 2, 1479 DOI: 10.1039/D1CB00132A

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