Issue 7, 2022

Peptide/protein-based macrocycles: from biological synthesis to biomedical applications

Abstract

Living organisms have evolved cyclic or multicyclic peptides and proteins with enhanced stability and high bioactivity superior to their linear counterparts for diverse purposes. Herein, we review recent progress in applying this concept to artificial peptides and proteins to exploit the functional benefits of these macrocycles. Not only have simple cyclic forms been prepared, numerous macrocycle variants, such as knots and links, have also been developed. The chemical tools and synthetic strategies are summarized for the biological synthesis of these macrocycles, demonstrating it as a powerful alternative to chemical synthesis. Its further application to therapeutic peptides/proteins has led to biomedicines with profoundly improved pharmaceutical performances. Finally, we present our perspectives on the field and its future developments.

Graphical abstract: Peptide/protein-based macrocycles: from biological synthesis to biomedical applications

Article information

Article type
Review Article
Submitted
17 12 2021
Accepted
08 6 2022
First published
09 6 2022
This article is Open Access
Creative Commons BY-NC license

RSC Chem. Biol., 2022,3, 815-829

Peptide/protein-based macrocycles: from biological synthesis to biomedical applications

W. Wu, J. Guo, L. Zhang, W. Zhang and W. Gao, RSC Chem. Biol., 2022, 3, 815 DOI: 10.1039/D1CB00246E

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