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Three 3-component copper(I)-based slider-on-deck systems served as catalysts for a click reaction showing a higher catalytic activity with increasing sliding speed. Upon addition of brake stones, the motion of the resulting 4-component machinery was slowed and eventually stopped (on the NMR time scale) with the effect that catalysis was reduced or obstructed.

Graphical abstract: Catalytic machinery in motion: controlling catalysis via speed

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