Issue 42, 2023

Crafting mono- and novel bis-methylated pyrroloquinoxaline derivatives from a shared precursor and its application in the total synthesis of marinoquinoline A

Abstract

The synthesis of mono- and novel bis-methylated pyrrolo[1,2-a]quinoxalines through the addition of unstable methyl radicals to aryl isocyanides is described contingent upon the reaction conditions employed. The strategy has been effectively employed in the total synthesis of the natural product marinoquinoline A.

Graphical abstract: Crafting mono- and novel bis-methylated pyrroloquinoxaline derivatives from a shared precursor and its application in the total synthesis of marinoquinoline A

Supplementary files

Article information

Article type
Paper
Submitted
31 8 2023
Accepted
03 10 2023
First published
10 10 2023
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2023,13, 29561-29567

Crafting mono- and novel bis-methylated pyrroloquinoxaline derivatives from a shared precursor and its application in the total synthesis of marinoquinoline A

M. Damai, N. Guzzardi, V. Lewis, Z. X. Rao, D. Sykes and B. Patel, RSC Adv., 2023, 13, 29561 DOI: 10.1039/D3RA05952A

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