Issue 9, 2024

A novel aurone RNA CAG binder inhibits the huntingtin RNA–protein interaction

Abstract

Huntington's disease (HD) is a devastating, incurable condition whose pathophysiological mechanism relies on mutant RNA CAG repeat expansions. Aberrant recruitment of RNA-binding proteins by mutant CAG hairpins contributes to the progress of neurodegeneration. In this work, we identified a novel binder based on an aurone scaffold that reduces the level of binding of HTT mRNA to the MID1 protein in vitro. The obtained results introduce aurones as a novel platform for the design of functional ligands for disease-related RNA sequences.

Graphical abstract: A novel aurone RNA CAG binder inhibits the huntingtin RNA–protein interaction

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Article information

Article type
Research Article
Submitted
01 6 2024
Accepted
14 7 2024
First published
17 7 2024
This article is Open Access
Creative Commons BY license

RSC Med. Chem., 2024,15, 3092-3096

A novel aurone RNA CAG binder inhibits the huntingtin RNA–protein interaction

G. Ballarin, M. Biasiotto, A. Reisbitzer, M. Hegels, M. Bolte, S. Krauß and D. V. Berdnikova, RSC Med. Chem., 2024, 15, 3092 DOI: 10.1039/D4MD00403E

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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