Issue 36, 2024

Improving reproducibility through condition-based sensitivity assessments: application, advancement and prospect

Abstract

The fluctuating reproducibility of scientific reports presents a well-recognised issue, frequently stemming from insufficient standardisation, transparency and a lack of information in scientific publications. Consequently, the incorporation of newly developed synthetic methods into practical applications often occurs at a slow rate. In recent years, various efforts have been made to analyse the sensitivity of chemical methodologies and the variation in quantitative outcome observed across different laboratory environments. For today's chemists, determining the key factors that really matter for a reaction's outcome from all the different aspects of chemical methodology can be a challenging task. In response, we provide a detailed examination and customised recommendations surrounding the sensitivity screen, offering a comprehensive assessment of various strategies and exploring their diverse applications by research groups to improve the practicality of their methodologies.

Graphical abstract: Improving reproducibility through condition-based sensitivity assessments: application, advancement and prospect

Supplementary files

Article information

Article type
Perspective
Submitted
08 5 2024
Accepted
29 8 2024
First published
30 8 2024
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2024,15, 14548-14555

Improving reproducibility through condition-based sensitivity assessments: application, advancement and prospect

F. Schäfer, L. Lückemeier and F. Glorius, Chem. Sci., 2024, 15, 14548 DOI: 10.1039/D4SC03017F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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