Issue 36, 2024

Nanoparticles constructed from natural polyphenols are used in acute kidney injury

Abstract

Acute kidney injury (AKI) is a severe clinical syndrome characterized by rapid deterioration of renal function caused by a variety of pathogeneses. Natural polyphenols have been considered to have potential in the treatment of AKI due to their powerful antioxidant and anti-inflammatory activities, but their low bioavailability in vivo limits their efficacy. Polyphenol nanoparticles based on a nano-delivery system show good effects in reducing kidney injury, improving renal function and promoting renal tissue repair, and brings new hope and possibility for the treatment of AKI. This review provides an overview of the common characteristics, treatments, and associated adverse effects of AKI. The classification and bioavailability of polyphenols as well as their therapeutic role in AKI and potential possible effects are outlined. The potential therapeutic effects of polyphenol-based nanoparticles on AKI and the underlying mechanisms are discussed.

Graphical abstract: Nanoparticles constructed from natural polyphenols are used in acute kidney injury

Article information

Article type
Review Article
Submitted
17 4 2024
Accepted
12 8 2024
First published
13 8 2024

J. Mater. Chem. B, 2024,12, 8883-8896

Nanoparticles constructed from natural polyphenols are used in acute kidney injury

X. Liu, Y. Guo, J. Pan, T. Wu, B. Zhao, S. Wei, W. Jiang and Y. Liu, J. Mater. Chem. B, 2024, 12, 8883 DOI: 10.1039/D4TB00837E

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