Issue 40, 2014

Investigating the reactivities of a polyketide synthase module through fluorescent click chemistry

Abstract

A method for monitoring in vitro polyketide synthesis has been developed whereby nonchromophoric polyketide products are made brightly fluorescent in a simple, rapid, inexpensive, and bioorthogonal manner through CuAAC with a sulforhodamine B azide derivative.

Graphical abstract: Investigating the reactivities of a polyketide synthase module through fluorescent click chemistry

Supplementary files

Article information

Article type
Communication
Submitted
01 10 2013
Accepted
29 10 2013
First published
29 10 2013

Chem. Commun., 2014,50, 5276-5278

Investigating the reactivities of a polyketide synthase module through fluorescent click chemistry

A. J. Hughes, M. R. Tibby, D. T. Wagner, J. N. Brantley and A. T. Keatinge-Clay, Chem. Commun., 2014, 50, 5276 DOI: 10.1039/C3CC47513A

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