Issue 6, 2022

Hierarchically porous MOF-based microneedles for glucose-responsive infected diabetic wound treatment

Abstract

Elaborately designed stimuli-responsive antibacterial systems are highly desirable for infected diabetic wound treatment. Herein, hierarchically porous metal–organic framework (MOF)-based glucose-responsive microneedles (MNs) were designed for painless transdermal wound treatment. For the first time, a hierarchically porous MOF was applied for consuming the surplus glucose to protect infected diabetic wounds from bacterial infection. Through one-pot synthesis, glucose oxidase (GOx) was firstly encapsulated into a Fe-doped zeolitic imidazolate framework (ZIF), and based on a properly controlled tannic acid (TA) etching process, the hierarchically porous MOF (GOx@Fe-ZIF-TA) was constructed afterwards. GOx encapsulated in GOx@Fe-ZIF-TA could consume surplus glucose in infected diabetic wounds to yield gluconic acid and H2O2. The latter could be catalyzed by Fe(II) to generate antibacterial ˙OH, which would not result in antimicrobial resistance. The as-obtained hierarchically porous MOF revealed satisfactory glucose-responsive antibacterial activity, and the hierarchically porous MOF-based MNs showed enough stiffness for penetration. This study offers a new strategy, using hierarchically porous enzyme-loaded MOFs as depots to integrate with MNs, for designing stimuli-responsive transdermal systems for the treatment of infected diabetic wounds and other diseases.

Graphical abstract: Hierarchically porous MOF-based microneedles for glucose-responsive infected diabetic wound treatment

Supplementary files

Article information

Article type
Research Article
Submitted
12 11 2021
Accepted
05 1 2022
First published
06 1 2022

Mater. Chem. Front., 2022,6, 680-688

Hierarchically porous MOF-based microneedles for glucose-responsive infected diabetic wound treatment

X. Yang, Y. Chen, P. Feng, C. Wang, X. Li, L. Liu and Y. Tang, Mater. Chem. Front., 2022, 6, 680 DOI: 10.1039/D1QM01512E

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